25 Jul
The BCR-ABL fusion gene is formed by a translocation between chromosomes 9 and 22 [t(9;22)]. The fusion gene is the hallmark diagnostic feature, being present in virtually all individuals with CML. It is also present in some adults and children with ALL. This assay aids in diagnosis of CML, identifying acute lymphoblastic leukemia (ALL) with t(9;22) BCR/ABL rearrangement (Ph+ ALL), selecting treatment inpatients with ALL, monitoring the effectiveness of therapy, monitoring minimal residual disease (MRD), and predicting disease progression.