Prenatal Testing by Fluorescence In Situ Hybridization (FISH)

Approximately half of clinically recognizable spontaneous abortions have a major chromosomal anomaly, out of which up to 95% involve aneuploidy (gain or loss of whole chromosome) of chromosomes 13, 18, 21, X, and
Y. FISH, which uses DNA probes, can rapidly detect aneuploidy of
13, 18, 21, X and Y.