25 Jul
Urine copper excretion is increased in Wilson disease due to a decreased serum binding of copper to ceruloplasmin, or
due to allelic variances in cellular metal ion transporters. Hypercupriuria is also found in hemochromatosis, biliary cirrhosis, thyrotoxicosis, infections, and malignant conditions. Hypocupriuria is seen in malnutrition, hypoproteinemias, malabsorption, and nephrotic syndrome.