25 Jul
Since the clinical symptoms of hepatitis E resemble those of other hepatitis, laboratory diagnostics play an essential role in diagnosis. Alongside PCR detection of viral RNA in blood or stool, the serological determination of antibodies is an important aid
for diagnosis of an HEV infection. Pathogen-specific antibodies are usually detectable when the first clinical symptoms appear or
shortly afterwards. A positive IgM and a significant increase in IgG in a serum pair (taken at a time interval of 8-14 days) indicate
an acute infection. IgM anti-HEV titers usually drop rapidly after infection, while the IgG HEV titer persists for over 10 years.