25 Jul
The Janus kinase 2 gene (JAK2) codes for a tyrosine kinase (JAK2) that is associated with the cytoplasmic portion of atype of transmembrane cytokine and growth factor receptors important for signal transduction. BCR-ABL1-negative myeloproliferative neoplasms commonly harbor an acquired single nucleotide mutation in JAK2 characterized as V617F. JAK2 V617F is present in 95% to 98% of polycythemia vera, 50% to 60% of primary myelofibrosis, and 50% to 60% of essential thrombocythemia.