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Neisseria Gonorrhoeae DNA Detection, PCR

Test Code: 22053 CPT Code: 87591
Specimen Type: Genital/ rectal swabs/ urine
Sample Volume: Swab: 1, culture/ urine: 5 mL
Transport Condition: Refrigerated condition/ room temperature
Specimen Rejection Criteria: Nil
Methodology: Multiplex-Real Time PCR
Special Requirements: Specimen source and clinical history required
Clinical Significance:

Gonorrhea, a very common sexually transmitted disease, is caused by the bacterium Neisseria gonorrhoeae. The organism causes genitourinary infections in women and men and may be associated with dysuria and vaginal, urethral, or rectal discharge. Nucleic acid amplification testing (NAAT) like Multiplex-Real Time PCR provides not only rapidity, but also superior sensitivityand specificity as compared to routine culture techniques.

Run Day: Sat, Tue
Reporting Day: 3rd day

Nicotine Metabolite, Urine

Test Code: 13002 CPT Code: 80323
Specimen Type: Urine
Sample Volume: 1 mL
Transport Condition: Refrigerated condition
Specimen Rejection Criteria: Nil
Methodology: Flow Chromatographic Immunoassay
Special Requirements: Collect a random urine specimen.No preservative.
Clinical Significance:

Tobacco use is the leading cause of death worldwide. Nicotine stimulates dopamine release and increases dopamine concentration in the nucleus accumbens,
a mechanism that is thought to be the basis for addiction for drugs of abuse. This assay is used for monitoring tobacco use and also for monitoring patients on nicotine-replacement therapy.

Run Day: Daily
Reporting Day: 3rd day

NIPT (Non Invasive Prenatal Test), for Trisomies 21, 18, 13

Test Code: 13737 CPT Code: 81507
Specimen Type:
Sample Volume: 10 mL
Transport Condition: Room temperature/ Refrigerated condition
Specimen Rejection Criteria: Sample collected in any other tube
Methodology: DNA sequencing by NGS paired-end sequencing technology
Special Requirements: The following information is required on the TRF supplied by the laboratory: Reason for referral, maternal age, number of fetuses, gestation age (weeks and days), method of determining gestational age, maternal height, maternal weight, whether IVF pregnancy, etc.
Clinical Significance:

Chromosomal aneuploidy is the leading genetic cause of miscarriage and congenital birth defects. This cell-free DNA prenatal screening enables de-tection of common chromosomal abnormalities, specifically aneuploidy including Down syndrome (trisomy 21), Patau syndrome (trisomy 13), and Edward syndrome (trisomy 18), without the risk of pregnancy loss associated with invasive prenatal procedures.

Run Day: Daily
Reporting Day: 15th day

NMDA Receptor Encephalitis Antibodies, IgG, Serum/ CSF

Test Code: 22045 CPT Code: 86256
Specimen Type: Serum (yellow-top tube)/ CSF
Sample Volume: Serum: 3.0mL (1.0 mL - min), CSF: 2.0 mL
Transport Condition: Refrigerated condition
Specimen Rejection Criteria: Gross hemolysis
Methodology: Immunofluorescent Assay
Special Requirements: Include relevant clinical information, name & phone number of ordering clinician.
Clinical Significance:

Anti-NMDA receptor encephalitis, also known as NMDA receptor antibody encephalitis, causes acute brain inflammation that is potentially lethal but has a high probability for recovery with treatment. It is caused by an immune system attack, primarily targeting the NR1 subunit of the NMDA receptor (N-methyl D-aspartate receptor). This assay aids in the diagnosis of anti-NMDA receptor encephalitis.

Run Day: Thurs
Reporting Day: Same day

Non-invasive Prenatal Genetic Testing for Fetal Chromosomal Aneuploidies (NIFTY)

Test Code: 9465 CPT Code: Use individual CPTCodes
Specimen Type: 3 mL blood in EDTA (lavender-top) tube; 5 mL in tube provided in kit
Sample Volume: Peripheral blood: 3mL & 5 mL
Transport Condition: Refrigerated condition
Specimen Rejection Criteria: Gross hemolysis
Methodology: NIFTY
Special Requirements: Clinical history in the predefined format along with patient consent is mandatory
Clinical Significance:

Refer report for details

Run Day: Daily
Reporting Day: 14th day


Test Code: 5789 CPT Code: 83880
Specimen Type: Heparinized venous whole blood in a green- top (heparin) tube
Sample Volume: 3.0 mL (1.0mL - min)
Transport Condition: Room temperature
Specimen Rejection Criteria: Serum collected in a yellow-top tube, Plasma
Methodology: POCT
Special Requirements: No special precautions needed
Clinical Significance:

Widely used clinical application of NT-proBNP testing is for the emergent diagnosis of CHF in patients presenting with acute dyspnea. Nevertheless, elevated NPs levels can be found in many conditions involving left ventricular dysfunction/ hypertrophy, right ventricular dysfunction secondary to pulmonary diseases, cardiac inflammatory/ infectious diseases, endocrine diseases
and high output status without decreased LV ejection fraction. Even in the absence of significant volume overload or LV dysfunction, markedly elevated proBNP levels can be found in patients with multiple comorbidities.

Run Day: Daily
Reporting Day: Same day